Assessment of brain iron accumulation in Alzheimer's disease with quantitative susceptibility mapping
نویسندگان
چکیده
منابع مشابه
Diagnosis of patients with Parkinson's disease using quantitative susceptibility mapping
Introduction: Parkinson'sdisease isassociated withirondeposition in the brain. The T2-weighted imaging, T2* mapping, R2 mapping and Quantitative Susceptibility Mapping (QSM) are three common methods to evaluating the iron deposition in brain. Among three methods the QSM is more sensitive than others. Few studies have been used QSM for evaluating the iron deposition in the basa...
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Introduction Quantitative susceptibility mapping (QSM) is a new contrast mechanism in magnetic resonance imaging (MRI). The images produced by the QSM enable researchers and clinicians to easily localize specific structures of the brain, such as deep brain nuclei. These nuclei are targets in many clinical applications and therefore their easy localization is a must. In this study, we aimed to i...
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BACKGROUND AND PURPOSE In patients with premanifest (nonsymptomatic) and advanced Huntington disease, changes in brain iron levels in the basal ganglia have been previously reported, especially in the striatum. Quantitative susceptibility mapping by using MR phase imaging allows in vivo measurements of tissue magnetic susceptibility, which has been shown to correlate well with iron levels in br...
متن کاملNon-Motor Symptom Burdens Are Not Associated with Iron Accumulation in Early Parkinson's Disease: a Quantitative Susceptibility Mapping Study
BACKGROUND Quantitative susceptibility mapping (QSM) has been used to measure iron accumulation in the deep nuclei of patients with Parkinson's disease (PD). This study examined the relationship between non-motor symptoms (NMSs) and iron accumulation in the deep nuclei of patients with PD. METHODS The QSM data were acquired from 3-Tesla magnetic resonance imaging (MRI) in 29 patients with ear...
متن کاملMeasurement of iron concentration in human brain using Quantitative Susceptibility Mapping (QSM): correlation with age
Introduction: Excessive iron deposition is often associated with neurodegenerative disorders, such as Parkinson’s disease (PD), Alzheimer’s disease and Huntington’s Chorea [1]. Quantitative measurement of regional iron deposition in the brain may help with diagnosis and assessment of disease progression. In order to use iron deposition as a new biomarker to stratify the stages of diseases, it i...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2020
ISSN: 1552-5260,1552-5279
DOI: 10.1002/alz.038799